São Paulo School of Advanced Science on pathogenic trypanosomatids: from basic biology to pathogenesis and new therapies

This SPSAS, focused on two parasites causing two neglected diseases that are endemic in the Americas, Leishmaniasis and Chagas disease, will occur in Ribeirão Preto. The SPSAS convey to the strong interdisciplinarity and brings together experts from different fields (molecular genetics using high throughput approaches, regulation of gene expression, structural biology, metabolism, epigenetic, drug design, among others).

Week 1

Week 2



  • Selma Jeronimo
    Natural history of Leishmania infantum infection in a changing world – epidemiology, clinical outcomes and host responses to infection.
  • Israel Molina
    Diagnostics and treatment of Chagas disease
    How to design a clinical for drugs against Chagas disease
  • Jeffrey Shaw
    Understanding leishmaniasis diversity
  • Paul Kaye
    Controlled Human Infection Models: development and utility for advancing leishmaniasis vaccines
  • Simona Stager
    Maintenance of CD4 T cell responses during experimental chronic visceral leishmaniasis.
  • Jeremy Mottram
    Genetic and chemical validation of protein kinases as drug targets in Leishmania
  • Pegine Walrad
    Trans-regulators and Leishmania epigenetics
  • Santuza Teixeira
    Manipulating the T. cruzi genome to understand gene expression and virulence
  • Maria Carolina S. Elias
    DNA replication in Trypanosomatids: licensing, direction and road conditions
  • Julia Cunha
    Epigenetics, phenotypic changes, and gene expression in Trypanosomes: a puzzle to be solved
  • Luiz Tosi
    How do tryps harness Replication Stress to organize and express their genomes?
  • Charles Mowbray
    How to build a drug discovery program for Neglected Tropical Diseases?
  • Glaucius Oliva
    Structural biology and drug discovery against infectious diseases circulating in Brazil
  • Kevin Read
    DMPK considerations in kinetoplastid drug discovery
  • Monica Pupo
    Natural Products as therapeutic agents against Trypanosomatids
  • Michael Barrett
    Metabolomics approaches to understanding drug mode of action and resistance in Leishmania
  • Susan Wyllie
    Title to be confirmed
  • Fernando Coelho
    Design and synthesis of new oxadiazole derivatives with activity against Chagas disease and Leishmaniasis
  • Marcelo Castilho
    In silico tools for drug design and discovery
  • Ian Gilbert
    Strategies for Drug Discovery for Neglected Infectious Diseases

Student will present their work in progress in 3 minutes (3 slides), advertising their work, which will be presented in full in the poster sessions.

All the students will present their work in progress in the poster sessions

Briefly, Group Activities will consist of an introduction that will be made by Jeremy Mottram on the general clues on grant writing and networks organizations. After that, the students will be divided in groups that will work on a scientific proposal. The elaboration of the proposals will take place during the course under our mentoring (8 professors will be available for discussions. The last task of each group will consist of making a public defense of the proposal.