São Paulo School of Advanced Science on pathogenic trypanosomatids: from basic biology to pathogenesis and new therapies
This SPSAS, focused on two parasites causing two neglected diseases that are endemic in the Americas, Leishmaniasis and Chagas disease, will occur in Ribeirão Preto. The SPSAS convey to the strong interdisciplinarity and brings together experts from different fields (molecular genetics using high throughput approaches, regulation of gene expression, structural biology, metabolism, epigenetic, drug design, among others).
- Selma Jeronimo
Natural history of Leishmania infantum infection in a changing world – epidemiology, clinical outcomes and host responses to infection.
- Israel Molina
Diagnostics and treatment of Chagas disease
How to design a clinical for drugs against Chagas disease
- Jeffrey Shaw
Understanding leishmaniasis diversity
- Paul Kaye
Controlled Human Infection Models: development and utility for advancing leishmaniasis vaccines
- Simona Stager
Maintenance of CD4 T cell responses during experimental chronic visceral leishmaniasis.
- Jeremy Mottram
Genetic and chemical validation of protein kinases as drug targets in Leishmania
- Pegine Walrad
Trans-regulators and Leishmania epigenetics
- Santuza Teixeira
Manipulating the T. cruzi genome to understand gene expression and virulence
- Maria Carolina S. Elias
DNA replication in Trypanosomatids: licensing, direction and road conditions
- Julia Cunha
Epigenetics, phenotypic changes, and gene expression in Trypanosomes: a puzzle to be solved
- Luiz Tosi
How do tryps harness Replication Stress to organize and express their genomes?
- Charles Mowbray
How to build a drug discovery program for Neglected Tropical Diseases?
- Glaucius Oliva
Structural biology and drug discovery against infectious diseases circulating in Brazil
- Kevin Read
DMPK considerations in kinetoplastid drug discovery
- Monica Pupo
Natural Products as therapeutic agents against Trypanosomatids
- Michael Barrett
Metabolomics approaches to understanding drug mode of action and resistance in Leishmania
- Susan Wyllie
Title to be confirmed
- Fernando Coelho
Design and synthesis of new oxadiazole derivatives with activity against Chagas disease and Leishmaniasis
- Marcelo Castilho
In silico tools for drug design and discovery
- Ian Gilbert
Strategies for Drug Discovery for Neglected Infectious Diseases
Student will present their work in progress in 3 minutes (3 slides), advertising their work, which will be presented in full in the poster sessions.
All the students will present their work in progress in the poster sessions
GRANT PITCHING AND GROUP ACTIVITIES:
Briefly, Group Activities will consist of an introduction that will be made by Jeremy Mottram on the general clues on grant writing and networks organizations. After that, the students will be divided in groups that will work on a scientific proposal. The elaboration of the proposals will take place during the course under our mentoring (8 professors will be available for discussions. The last task of each group will consist of making a public defense of the proposal.